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KMID : 0384320160370060310
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Korean Journal of Family Medicine
2016 Volume.37 No. 6 p.310 ~ p.316
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Common Analgesic Agents and Their Roles in Analgesic Nephropathy: A Commentary on the Evidence
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Julian Yaxley
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Abstract
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An association between non-opioid analgesic agents and chronic kidney disease has long been suspected. The presumed development of chronic renal impairment following protracted and excessive use of non-opioid analgesia is known as analgesic nephropathy. Many clinicians accept analgesic nephropathy as a real entity despite the paucity of scientific evidence. This narrative review aims to summarize the literature in the field. The weight of available observational literature suggests that long-term ingestion of paracetamol and combination mixtures of aspirin and paracetamol are likely to contribute to chronic renal impairment. However, there is no convincing data to implicate non-steroidal anti-inflammatory drugs or aspirin monotherapy in the development of analgesic nephropathy. In the absence of high-level evidence, while controversy persists, it may be prudent for physicians to consider all non-narcotic analgesics to be nephrotoxic with long-term use.
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KEYWORD
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Nephropathy, Analgesics, Renal Insufficiency
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